Microdilution growth assays were used to assess the minimum inhibitory concentration (MIC) of antibiotics and honey against S. Aureus strains. Routine static growth conditions were used against S. We adjusted for NAI treatment propensity and preadmission antibiotic use steroid, including study center as a random intercept to account for differences in baseline hospitalization rate between centers.Results: We included 3376 patients with influenza A(H1N1)pdm09, of whom 3085 (91.4%) had laboratory confirmed infection. Eight hundred seventy three patients (25.8%) received outpatient or community based NAI treatment steroid steroid, 928 of 2395 (38.8%) with available data had dyspnea or respiratory distress, and hospitalizations occurred in 1705 (50.5%). After adjustment for preadmission antibiotics and NAI treatment propensity, preadmission NAI treatment was associated with decreased odds of hospital admission compared to no NAI treatment (adjusted odds ratio, 0.24; 95% confidence interval, 0.20 “0.30).Conclusions: In a population with confirmed or suspected A(H1N1)pdm09 and at high risk of hospitalization, outpatient or community based NAI treatment significantly reduced the likelihood of requiring hospital admission.
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